Pancreatic cancer adenocarcinoma (PDAC) is a dire disease with no good treatment and a five-year survival of only 5%. While most PDAC studies focus on cancer initiation and driver mutations, the majority of patients come to the clinic already with a metastatic disease, most frequently with liver metastasis, and most die directly from metastases.The research...
The liver has a remarkable ability to renew itself in a process called regeneration- regrowth of liver tissue following partial resection or injury. This is already documented in Greek mythology relating to Prometheus, who stole fire from the gods and granted it to humans. He was punished by being chained to a cliff, and every...
Fragile X syndrome (FXS), the most common form of inherited intellectual disability, is caused by a developmentally regulated silencing of the FMR1 gene, but its effect on human neuronal network development and function is not fully understood. Here we isolated isogenic human embryonic stem cell subclones one with a full FX mutation and one that...
Breast cancer is the most common type of cancer among women, with highest death cases, and when the disease is metastatic, it is incurable. The most common type of breast cancer expresses the estrogen receptor. Hormone therapy is very effective in women with this type of metastatic breast cancer, but over time the tumor stops...
