Articles

From genomic analysis to deciphering development of pancreatic cancer liver metastasis

Pancreatic cancer adenocarcinoma (PDAC) is a dire disease with no good treatment and a five-year survival of only 5%. While most PDAC studies focus on cancer initiation and driver mutations, the majority of patients come to the clinic already with a metastatic disease, most frequently with liver metastasis, and most die directly from metastases.The...

Impaired functional connectivity underlies Fragile-X syndrome

Fragile X syndrome (FXS), the most common form of inherited intellectual disability, is caused by a developmentally regulated silencing of the FMR1 gene, but its effect on human neuronal network development and function is not fully understood. Here we isolated isogenic human embryonic stem cell subclones one with a full FX mutation and one...

Breast cancer

Breast cancer is the most common type of cancer among women, with highest death cases, and when the disease is metastatic, it is incurable. The most common type of breast cancer expresses the estrogen receptor. Hormone therapy is very effective in women with this type of metastatic breast cancer, but over time the tumor...

Myelin Repair in Multiple Sclerosis

Myelin Repair in Multiple Sclerosis In Dr. Arnon Karni's laboratory, molecules have been found to accelerate the repair processes of the affected myelin in multiple sclerosis (MS). MS is an autoimmune neurological disease, in which many foci of inflammation are formed in the central nervous system. The inflammation leads to the destruction of the myelin sheaths,...