The Genomic Research Laboratory for Lung Fibrosis, Dr. Avraham (Rami) Unterman >>

The Genomic Research Laboratory for Lung Fibrosis

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Our Vision

To uncover the basic mechanisms underlying lung fibrosis and develop new treatments - Interstitital lung diseases (ILDs) consist of over 200 different diseases. Many patients, in particular those who are diagnosed with idiopathic pulmonary fibrosis (IPF), develop severe lung scarring (called lung fibrosis) that necessitates lung transplantation for survival, including some who recover from COVID-19. Despite multidisciplinary approaches to diagnose ILD patients, in many cases the exact diagnosis is unclear. Furthermore, current treatment options may delay disease progression but cannot provide cure. In our laboratory, we employ cutting-edge genomic technologies, including single cell RNA sequencing (scRNA-seq), to study ILD patient-derived samples. We believe that by using scRNA-seq, we may come one step closer towards elucidating the biology of these intricate diseases, identify new biomarkers and develop novel treatments for ILD patients.

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Contact Us

Primary Investigators
Dr Unterman PI Small picture

Dr. Avraham (Rami) Unterman, MD, MBA, Lab PI

Head of the Multidisciplinary Pulmonary Fibrosis Service and PI of the Genomic Research Laboratory for Lung Fibrosis,Pulmonary Institute 03-697‏2552‏ ramiu@tlvmc.gov.il

Dr Stein Lab Manager small pic

Yan Stein, PhD, Lab manager

03-697‏2552‏ yanst@tlvmc.gov.il

General Contact
Address

Sammy Ofer Heart ‎ Building

10th floor Room 64-65

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Research

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Our Team

Current Staff

Researchers

Clinical Research Coordinator

Research Assistant

Current funding

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Highlight Publications

Single-Cell Profiling Reveals Immune Aberrations in Progressive Idiopathic Pulmonary Fibrosis.

Unterman A, Zhao AY, Neumark N, Schupp JC, Ahangari F, Cosme C Jr, Sharma P, Flint J, Stein Y, Ryu C, Ishikawa G, Sumida TS, Gomez JL, Herazo-Maya JD, Dela Cruz CS, Herzog EL, Kaminski N. Am J Respir Crit Care Med. 2024. doi: 10.1164/rccm.202306-0979OC


Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19.

Unterman A, Sumida TS, Nouri N, Yan X, Zhao AY, Gasque V, Schupp JC, Asashima H, Liu Y, Cosme C Jr, Deng W, Chen M, Raredon MSB, Hoehn KB, Wang G, Wang Z, DeIuliis G, Ravindra NG, Li N, Castaldi C, Wong P, Fournier J, Bermejo S, Sharma L, Casanovas-Massana A, Vogels CBF, Wyllie AL, Grubaugh ND, Melillo A, Meng H, Stein Y, Minasyan M, Mohanty S, Ruff WE, Cohen I, Raddassi K; Yale IMPACT Research Team, Niklason LE, Ko AI, Montgomery RR, Farhadian SF, Iwasaki A, Shaw AC, van Dijk D, Zhao H, Kleinstein SH, Hafler DA, Kaminski N, Dela Cruz CS. Nat Commun. 2022 Jan 21;13(1):440.

Blood Transcriptomic Predicts Progression of Pulmonary Fibrosis and Associates Natural Killer Cells. SHuang Y, Oldham JM, Ma SF, Unterman A, Liao SY, Barros AJ, Bonham CA, Kim JS, Vij R, Adegunsoye A, Strek ME, Molyneaux PL, Maher TM, Herazo-Maya JD, Kaminski N, Moore BB, Martinez FJ, Noth I.

Am J Respir Crit Care Med. 2021;204:197-208 (In Press).

Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children. Ramaswamy A, Brodsky NN, Sumida TS, Comi M, Asashima H, Hoehn KB, Li N, Liu Y, Shah A, Ravindra NG, Bishai J, Khan A, Lau W, Sellers B, Bansal N, Guerrerio P, Unterman A, Habet V, Rice AJ, Catanzaro J, Chandnani H, Lopez M, Kaminski N, Dela Cruz CS, Tsang JS, Wang Z, Yan X, Kleinstein SH, van Dijk D, Pierce RW, Hafler DA, Lucas CL
Immunity 2021; 54(5):1083-1095.e7.

More Publications >>

. Cutting Edge: Distinct B Cell Repertoires Characterize Patients with Mild and Severe COVID-19 Hoehn KB, Ramanathan P, Unterman A, Sumida TS, Asashima H, Hafler DA, Kaminski N, Dela Cruz CS, Sealfon SC, Bukreyev A, Kleinstein SH
J Immunol 2021;206(12):2785-2790.

. Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells Sumida TS, Dulberg S, Schupp J, Stillwell HA, Axisa PP, Comi M, Lincoln M, Unterman A, Kaminski N, Madi A, Kuchroo VK, Hafler DA
BioRxiv 2020 (pre-print). Under review in Nature Immunology

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