Surgical Oncology Research Laboratory – Dr. Eran Nizri >>

Surgical Oncology Research Laboratory


Our Vision

Our lab aims to advance medical knowledge and improve patient outcomes by innovative basic and translational research in the field of surgical oncology. Our vision is to develop new and transformative technologies and introduce them into clinical practice. Our unique position as a research lab affiliated to a busy surgical oncology department, supplant us with human biological samples and a clinical point of view. On the translation aspect, our lab has a special focus on biomarkers for efficacy of heated intra-peritoneal chemotherapy (HIPEC) for patients with peritoneal surface malignancies. In addition, we are exploring novel diagnostic modalities for severe post-operative complications, such as anastomotic leakage. On the basic science aspect, we are interested in the immunological response to peritoneal metastasis from colorectal cancer, and have developed specific experimental model to decipher the tumor micro-environment of peritoneal metastases. We are committed to fostering a culture of collaboration and innovation, bringing together physicians and scientists from diverse backgrounds to tackle major problems in cancer care.


Contact Us

Primary Investigators
ערן ניזרי

Dr. Eran Nizri , Lab PI


picture for website

Kelly Lipczyc , Lab manager

Phone: +972-58-5109645


Sammy Ofer Heart Building

10th floor‎ Room 64-65
‎6 weizmann st.‎, Tel Aviv



Prediction of long-term outcomes from lavage fluid after CRS+HIPEC in patients with peritoneal surface malignancies
There is an ongoing debate on the effectiveness of heated intra-peritoneal chemotherapy (HIPEC) in the management of patients with peritoneal surface malignancies (PSM). HIPEC is intended to kill any remaining tumor cells in the peritoneal cavity after the macroscopic disease has been surgically resected but there is currently no widely accepted method of measuring chemotherapy effectiveness. Therefore, it is important to establish the efficacy of HIPEC in treating patients with peritoneal malignancies, as well as to develop biological criteria that will help us quantify the effect of HIPEC and its relationship with long-term survival. Our aim is to measure specific markers present in HIPEC effluent and establish a correlation with long-term outcomes. 


Predicting postoperative complications using biological markers extracted from drainage fluid
Anastomotic leakage is a relatively common postoperative complication, occurring between 5% and 15% of surgeries performed along the digestive tract. Despite improvements in surgical techniques and perioperative management, the overall incidence of leakage does not appear to be decreasing. Such a leak involves a serious intra-abdominal infection, which may lead to sepsis and life-threatening complications. Early diagnosis of leaks is crucial because timely intervention can prevent the patient’s condition from deteriorating and causing damage to multiple systems. Early detection and prediction will allow the administration of antibiotics ahead of time, as well as the scheduling of surgeries or other medical operations designed to control the leak. Our working assumption is that there exist biological markers which can help us predict when a patient is at risk of leaking ahead of time. By analyzing abdominal fluid extracted from drains left during surgery we may be able to detect clues to the development of a leak before it becomes a serious problem.
3D Printed Thermoresponsive Scaffolds for Adipose Tissue Regeneration after Breast Conserving Surgery

Adenocarcinoma of the breast is the most common cancer in women in the western world, and the second leading cause of cancer-related deaths. Studies conducted over the last decades have demonstrated that breast conserving surgery (BCS), i.e. lumpectomy, provides similar long term survival to resection of the whole breast, i.e. mastectomy. However, BCS pose a significant cosmetic challenge, as it mandatorily creates breast asymmetry due to resection of the tumor mass and its adjacent healthy tissue from one breast. To address this issue, intensive research has been dedicated to tissue engineering-based solutions. Tissue engineering seeks to develop biological substitutes utilizing cells and materials that restore, maintain, or improve tissue function. The focus of this study is to develop a personalized 3D-printed scaffold for tissue regeneration to be used in BCS.


Our Team

Current Staff


Past Staff

Current funding


Highlighted Publications

PD-1 Blockade Combined with Heated Intraperitoneal Chemotherapy Improves Outcome in Experimental Peritoneal Metastases from Colonic Origin in a Murine Model.

Geva R, Alon G, Nathanson M, Bar-David S, Nevo N, Aizic A, Peles-Avraham S, Lahat G, Nizri E. Ann Surg Oncol. 2023 May;30(5):2657-2663.

Immunological effects of heated intraperitoneal chemotherapy can be augmented by thymosin α1.  

Nevo N, Lee Goldstein A, Bar-David S, Abu-Abeid A, Dayan D, Lahat G, Nizri E. Int Immunopharmacol. 2023 Mar;116:109829.


More Publications >>

Thymosin alpha 1 as an adjuvant to hyperthermic intraperitoneal chemotherapy in an experimental model of peritoneal metastases from colonic carcinoma.

Nevo N, Lee Goldstein A, Bar-David S, Natanson M, Alon G, Lahat G, Nizri E. Int Immunopharmacol. 2022 Oct;111:109166.

Long-term outcomes of elderly patients with peritoneal metastases of colorectal origin after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.

Weksler Y, Hoffman A, Green E, Kyzer M, Nevo N, Gerstenhaber F, Greenberg R, Klausner JM, Gutman M, Lahat G, Berger Y, Geva R, Nizri E. Surg Oncol. 2022 Sep;44:101848.

Innate inflammatory markers for predicting survival in retroperitoneal sarcoma.  

Netanyahu Y, Gerstenhaber F, Shamai S, Sher O, Merimsky O, Klausner JM, Lahat G, Nizri E. J Surg Oncol. 2020 Dec;122(8):1655-1661. 

Protective Desmoplasia in Pancreatic Adenocarcinoma: High Vitamin D Receptor Expression and Collagen Content. 

Bahat AV, Bar-David S, Brooks A, Aizic A, Greenberg O, Wolf I, Klausner JM, Lahat G, Nizri E. Anticancer Res. 2020 Nov;40(11):6457-6464. 

Size and lipid modification determine liposomal Indocyanine green performance for tumor imaging in a model of rectal cancer.

Bar-David S, Larush L, Goder N, Aizic A, Zigmond E, Varol C, Klausner J, Magdassi S, Nizri E. Sci Rep. 2019 Jun 12;9(1):8566. 


Optimization of liposomal indocyanine green for imaging of the urinary pathways and a proof of concept in a pig model.

Friedman-Levi Y, Larush L, Diana M, Marchegiani F, Marescaux J, Goder N, Lahat G, Klausner J, Eyal S, Magdassi S, Nizri E. Surg Endosc. 2018 Feb;32(2):963-970.


Less Publications >>


From The Press