Inherited eye disease research center
R&D > Laboratories > Inherited eye disease research center – Dr. Moshe Giladi
Our Vision
Our research goal is to understand the molecular mechanisms underlying human diseases caused by genetic mutations, with a special emphasis on inherited eye diseases. With these mechanistic insights, we develop novel and specific therapeutics by utilizing high-throughput drug screening approaches.
Contact Us
Primary Investigators
Dr. Moshe Giladi - Lab PI
Physician, Internal Medicine D;Dept. of Physiology and Pharmacology
Email: moshegil@tau.ac.il
Address
Sammy Ofer Heart Building
10 floor Room 12
Research
Retinitis pigmentosa (RP) is the most common inherited form of retinal degeneration, ultimately leading to blindness. Despite the major advancements in elucidating the genetic causes for RP, it remains incurable to date. In recent years, a growing number of disease-causing mutations in DHDDS were identified, leading to diverse clinical presentations including RP and severe neurological diseases. We have determined the atomic-resolution structure of the enzymatic complex in which DHDDS is involved and use this information to investigate its function in health and disease, as well as to develop targeted therapies for RP. |
Post-translational protein modifications (PTM) are crucial for protein folding, function, and cellular localization in every cell in the human body. These modifications were highlighted in cancerous transformation, metastasis, and response to treatments. However, no specific treatments targeting aberrant PTM are currently available for clinical use. By studying key enzymes involved in the synthesis of moieties for PTM, we use a structure-guided approach to develop novel and specific cancer therapies.
Gallery
Our Team
Current Staff
Students
- Ruba Yehia, Ph.D. student
- Bar Manori, M.Sc. student
- Suha Abed Alkader, M.Sc. student
Collaborator
- Dr. Yoni Haitin, Ph.D. Dept. of Physiology and Pharmacology, Tel Aviv University.
Past Staff
Current funding
Highlight Publications
Refaeli B, Liu S, Hiller R, Giladi M, Baiz CR, Khananshvili D. Cell Calcium. 2021 Nov;99:102476. |
Kellner S, Abbasi A, Carmi I, Heinrich R, Garin-Shkolnik T, Hershkovitz T, Giladi M, Haitin Y, Johannesen KM, Steensbjerre Møller R, Berlin S. Elife. 2021 Jul 2;10:e67555. |
Bar-El ML, Vaňková P, Yeheskel A, Simhaev L, Engel H, Man P, Haitin Y, Giladi M. Nat Commun. 2020 Oct 19;11(1):5273. |
More Publications >>
Fadila S, Quinn S, Turchetti Maia A, Yakubovich D, Ovadia M, Anderson KL, Giladi M, Rubinstein M. Epilepsia. 2020 Oct;61(10):2289-2300. |
Ferofontov A, Vankova P, Man P, Giladi M, Haitin Y. FASEB J. 2020 Aug;34(8):9925-9940. |
Ben-Bassat A, Giladi M, Haitin Y. |
J Gen Physiol. 2020 Apr 6;152(4):e201912505.
Giladi M, Khananshvili D. Front Pharmacol. 2020 Feb 19;11:70. |
Iwaki M, Refaeli B, van Dijk L, Hiller R, Giladi M, Kandori H, Khananshvili D. FEBS J. 2020 Nov;287(21):4678-4695. |
Lisnyansky Bar-El M, Lee SY, Ki AY, Kapelushnik N, Loewenstein A, Chung KY, Schneidman-Duhovny D, Giladi M, Newman H, Haitin Y. |
Biomolecules. 2019 Oct 28;9(11):660.
Lisnyansky M, Yariv E, Segal O, Marom M, Loewenstein A, Ben-Tal N, Giladi M, Haitin Y. Mol Pharmacol. 2019 Nov;96(5):580-588. |
Giladi M, Lee SY, Refaeli B, Hiller R, Chung KY, Khananshvili D. Biochim Biophys Acta Bioenerg. 2019 Mar 1;1860(3):189-200. |
Lisnyansky M, Kapelushnik N, Ben-Bassat A, Marom M, Loewenstein A, Khananshvili D, Giladi M, Haitin Y. Mol Pharmacol. 2018 Dec;94(6):1391-1400. |
Key residues controlling bidirectional ion movements in Na+/Ca2+ exchanger. van Dijk L, Giladi M, Refaeli B, Hiller R, Cheng MH, Bahar I, Khananshvili D. Cell Calcium. 2018 Dec;76:10-22. |
Inherent flexibility of CLIC6 revealed by crystallographic and solution studies. Ferofontov A, Strulovich R, Marom M, Giladi M, Haitin Y. Sci Rep. 2018 May 2;8(1):6882. |
Padala P, Soudah N, Giladi M, Haitin Y, Isupov MN, Wiener R. J Mol Biol. 2017 Dec 8;429(24):3801-3813. |
Overexpression and Purification of Human Cis-prenyltransferase in Escherichia coli. Edri I, Goldenberg M, Lisnyansky M, Strulovich R, Newman H, Loewenstein A, Khananshvili D, Giladi M, Haitin Y. J Vis Exp. 2017 Aug 3;(126):56430. |
Giladi M, van Dijk L, Refaeli B, Almagor L, Hiller R, Man P, Forest E, Khananshvili D. |
J Biol Chem. 2017 Jul 21;292(29):12311-12323.
Structure-based dynamic arrays in regulatory domains of sodium-calcium exchanger (NCX) isoforms.
Giladi M, Lee SY, Ariely Y, Teldan Y, Granit R, Strulovich R, Haitin Y, Chung KY, Khananshvili D.
Sci Rep. 2017 Apr 20;7(1):993.
Giladi M, Edri I, Goldenberg M, Newman H, Strulovich R, Khananshvili D, Haitin Y, Loewenstein A. Protein Expr Purif. 2017 Apr;132:138-142. |
