Macrophages regulate almost every tissue in the body, and play crucial roles in pathophysiology of chronic diseases. Therefore, regulating them has the potential to facilitate recovery. We study the involvement of these cells in diseases of the digestive tract and metabolic syndrome, such as: obesity, colorectal cancer, hepatocellular carcinoma, liver damage, non-alcoholic steatohepatitis (NASH), and inflammatory bowel diseases (IBD). We strive to understand the role of COMMD proteins, master regulators of NF-kB and cargo-specific intracellular trafficking, in controlling the function of macrophages in these diseases. We extensively utilize animal models, human patient samples and diverse molecular approaches. We have shown that COMMD10 plays an important role in restraining inflammasome activation in Ly6Chi monocytes in experimental models of sepsis and colitis (Mouhadeb, Front Immunology, 2017). We also uncovered an important role for COMMD10 in facilitating phagolysosomal biogenesis and maturation in liver Kupffer cells, being essential for timely clearance of staphylococcal aureus infection (Ben Shlomo, iScience, 2018). COMMD10 is a fundamental factor in maintenance of tissue-resident macrophages and also in regulation of monocyte differentiation and inflammatory behavior during drug-induced liver injury (Cohen et al, Cell Reports, 2021). We hold regular meetings for presenting findings, discussion and brainstorming. Our findings are presented repeatedly in scientific meetings locally and abroad. Our reasearch group is well-funded. We are looking for bright and curious students and will provide them with a nurturing mentorship that strives to educate for independent thinking.