Inflammatory research Laboratory – Dr. Shani Shenhar-Tsarfaty >>

Inflammatory Research Laboratory

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Our Vision

Our current research deals with the regulation and kinetics of inflammation at different post-transcriptional levels of gene expression, in multiple clinical models such as stroke, myocardial infarction, metabolic disorders, anesthesia and dementia.
Main research topics:
1. Cholinergic regulation of stress and inflammation.
2. Kinetic of inflammatory responses.
3. Urine proteomic for detection of Mega-inflammation.
4. Exercise-induced urinary protein secretion as an early marker for kidney injury.

Research methods include basic molecular biology as well as sophisticated statistical models

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Contact Us

Primary Investigators
Shani pic

Dr. Shani Shenhar-Tsarfaty, Lab Manager

050-4092256 shanis@tlvmc.gov.il

Address

Sammy Ofer Heart Building

10th floor Room 72

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Research

Cholinergic regulation of stress and inflammation‎

Imbalanced autonomic nervous system (ANS) activity is associated with poor cardiovascular outcome. However, clinically validated biomarkers to assess parasympathetic function are not yet available. We sought to evaluate parasympathetic dysfunction by measuring serum cholinesterase activity and to determine its relationship to stress and inflammation

Kinetic of inflammatory responses‎

Our study focus on using the dynamics of a biomarker, rather than single value, in order to evaluate patient’s risk. We study longitudinal data to correlate with disease prognosis. We have recently published that the  kinetics of C-reactive protein response can improve the differential diagnosis between acute bacterial and viral infections.

Urine proteomic for detection of Mega-inflammation‎

We study the use of urinary biomarkers for early and non-invasive determination of the intensity of inflammation, and for evaluation of risks associated therewith

Exercise-induced urinary protein secretion as an early marker for kidney injury

Measuring Exercise induced albuminuria  is a potential new sensitive and early biomarker for the kidney’s “reservoir capacities”, endothelial dysfunction and other metabolic related end organ damage. We use the exercise stress test to challenge not only the heart but also the kidney functions

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Our Team

Current Staff

Lab PI

Researchers & Students

Past Staff

Current funding

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Highlight Publications

Cholinesterase activity in serum during general anesthesia in patients with or without vascular disease.

Brzezinski-Sinai Y, Zwang E, Plotnikova E, Halizov E, Shapira I, Zeltser D, Rogowski O, Berliner S, Matot I, Shenhar-Tsarfaty S. Sci Rep. 2021 Aug 17;11(1):16687

Non-alcoholic Fatty Liver and Liver Fibrosis Predictive Analytics: Risk Prediction and Machine Learning Techniques for Improved Preventive Medicine.

Goldman O, Ben-Assuli O, Rogowski O, Zeltser D, Shapira I, Berliner S, Zelber-Sagi S, Shenhar-Tsarfaty S.J Med Syst. 2021 Jan 11;45(2):22

 

 

Transfer RNA fragments replace microRNA regulators of the cholinergic poststroke immune blockade.

Winek K, Lobentanzer S, Nadorp B, Dubnov S, Dames C, Jagdmann S, Moshitzky G, Hotter B, Meisel C, Greenberg DS, Shifman S, Klein J, Shenhar-Tsarfaty S, Meisel A, Soreq H.Proc Natl Acad Sci U S A. 2020 Dec 22;117(51):32606-32616

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Blood acetylcholinesterase activity is associated with increased 10 year all-cause mortality following coronary angiography.

Shenhar-Tsarfaty S, Brzezinski RY, Waiskopf N, Finkelstein A, Halkin A, Berliner S, Rogowski O, Zeltser D, Shapira I, Laufer-Perl M, Shacham Y, Litmanowicz B, Banai S, Soreq H, Arbel Y.Atherosclerosis. 2020 Nov;313:144-149

Exercise-induced albuminuria increases over time in individuals with impaired glucose metabolism.

Brzezinski RY, Friedensohn L, Shapira I, Zeltser D, Rogowski O, Berliner S, Grupper A, Shenhar-Tsarfaty S.Cardiovasc Diabetol. 2020 Jun 15;19(1):90.

Using the kinetics of C-reactive protein response to improve the differential diagnosis between acute bacterial and viral infections.

Coster D, Wasserman A, Fisher E, Rogowski O, Zeltser D, Shapira I, Bernstein D, Meilik A, Raykhshtat E, Halpern P, Berliner S, Shenhar-Tsarfaty S, Shamir R.Infection. 2020 Apr;48(2):241-248

 

 

Anemia measurements to distinguish between viral and bacterial infections in the emergency department.

Steuerman Y, Wasserman A, Zeltser D, Shapira I, Trotzky D, Halpern P, Meilik A, Raykhshtat E, Berliner S, Rogowski O, Gat-Viks I, Shenhar-Tsarfaty S.Eur J Clin Microbiol Infect Dis. 2019 Dec;38(12):2331-2339

Hypertension is associated with increased post-exercise albuminuria, which may be attenuated by an active lifestyle.

Grupper A, Ehrenwald M, Schwartz D, Berliner S, Shashar M, Baruch R, Schwartz IF, Rogowski O, Zeltser D, Shapira I, Shenhar-Tsarfaty S.J Clin Hypertens (Greenwich). 2019 Aug;21(8):1171-1179

Exercise-induced cardiac troponin in the era of high sensitivity assays: What makes our heart sweat?

Brzezinski RY, Milwidsky A, Shenhar-Tsarfaty S.Int J Cardiol. 2019 Aug 1;288:19-21.

 

Increase of body mass index and waist circumference predicts development of metabolic syndrome criteria in apparently healthy individuals with 2 and 5 years follow-up.

Fisher E, Brzezinski RY, Ehrenwald M, Shapira I, Zeltser D, Berliner S, Marcus Y, Shefer G, Stern N, Rogowski O, Halperin E, Rosset S, Shenhar-Tsarfaty S.Int J Obes (Lond). 2019 Apr;43(4):800-807

Obesity-related acetylcholinesterase elevation is reversed following laparoscopic sleeve gastrectomy.

Shenhar-Tsarfaty S, Sherf-Dagan S, Berman G, Webb M, Raziel A, Keidar A, Goitein D, Sakran N, Zwang E, Shapira I, Zeltser D, Berliner S, Rogowski O, Shibolet O, Zelber-Sagi S.Int J Obes (Lond). 2019 Feb;43(2):297-305.

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