Inflammatory Research Laboratory
R&D > Laboratories > Inflammatory Research Laboratory
Our Vision
Our current research deals with the regulation and kinetics of inflammation at different post-transcriptional levels of gene expression, in multiple clinical models such as stroke, myocardial infarction, metabolic disorders, anesthesia and dementia.
Main research topics:
1. Cholinergic regulation of stress and inflammation.
2. Kinetic of inflammatory responses.
3. Urine proteomic for detection of Mega-inflammation.
4. Exercise-induced urinary protein secretion as an early marker for kidney injury.
Research methods include basic molecular biology as well as sophisticated statistical models
Contact Us
Primary Investigators
Noa Sasson,Lab PI
03-6947240 noasas@tlvmc.gov.il
Address
Sammy Ofer Heart Building
10th floor Room 72
Research
Imbalanced autonomic nervous system (ANS) activity is associated with poor cardiovascular outcome. However, clinically validated biomarkers to assess parasympathetic function are not yet available. We sought to evaluate parasympathetic dysfunction by measuring serum cholinesterase activity and to determine its relationship to stress and inflammation
Our study focus on using the dynamics of a biomarker, rather than single value, in order to evaluate patient’s risk. We study longitudinal data to correlate with disease prognosis. We have recently published that the kinetics of C-reactive protein response can improve the differential diagnosis between acute bacterial and viral infections.
We study the use of urinary biomarkers for early and non-invasive determination of the intensity of inflammation, and for evaluation of risks associated therewith
Measuring Exercise induced albuminuria is a potential new sensitive and early biomarker for the kidney’s “reservoir capacities”, endothelial dysfunction and other metabolic related end organ damage. We use the exercise stress test to challenge not only the heart but also the kidney functions
Gallery
Our Team
Current Staff
Lab PI
- Shani Shenhar-Tsarfaty, PhD
- Prof. Shlomo Berliner, MD, PhD
- Prof. Ori Rogowski, MD
Researchers & Students
- Rafi Brzezinski, MD-PhD
- Etti Zwang, BSc.
- Rony Izhar, PhD
- Hadas Ben-Assayag, Md student
- Nitzan Dayan
Past Staff
- Noa Cohen
- Rotem Moshe
- Esti Halizov
- Eyal Fisher
- Inbal Etz Hadar, BSc
- Inna Meilik, BSc
Current funding
Highlight Publications
Brzezinski-Sinai Y, Zwang E, Plotnikova E, Halizov E, Shapira I, Zeltser D, Rogowski O, Berliner S, Matot I, Shenhar-Tsarfaty S. Sci Rep. 2021 Aug 17;11(1):16687
Goldman O, Ben-Assuli O, Rogowski O, Zeltser D, Shapira I, Berliner S, Zelber-Sagi S, Shenhar-Tsarfaty S.J Med Syst. 2021 Jan 11;45(2):22
Transfer RNA fragments replace microRNA regulators of the cholinergic poststroke immune blockade. Winek K, Lobentanzer S, Nadorp B, Dubnov S, Dames C, Jagdmann S, Moshitzky G, Hotter B, Meisel C, Greenberg DS, Shifman S, Klein J, Shenhar-Tsarfaty S, Meisel A, Soreq H.Proc Natl Acad Sci U S A. 2020 Dec 22;117(51):32606-32616 |
More Publications >>
Shenhar-Tsarfaty S, Brzezinski RY, Waiskopf N, Finkelstein A, Halkin A, Berliner S, Rogowski O, Zeltser D, Shapira I, Laufer-Perl M, Shacham Y, Litmanowicz B, Banai S, Soreq H, Arbel Y.Atherosclerosis. 2020 Nov;313:144-149
Exercise-induced albuminuria increases over time in individuals with impaired glucose metabolism.
Brzezinski RY, Friedensohn L, Shapira I, Zeltser D, Rogowski O, Berliner S, Grupper A, Shenhar-Tsarfaty S.Cardiovasc Diabetol. 2020 Jun 15;19(1):90.
Coster D, Wasserman A, Fisher E, Rogowski O, Zeltser D, Shapira I, Bernstein D, Meilik A, Raykhshtat E, Halpern P, Berliner S, Shenhar-Tsarfaty S, Shamir R.Infection. 2020 Apr;48(2):241-248
Steuerman Y, Wasserman A, Zeltser D, Shapira I, Trotzky D, Halpern P, Meilik A, Raykhshtat E, Berliner S, Rogowski O, Gat-Viks I, Shenhar-Tsarfaty S.Eur J Clin Microbiol Infect Dis. 2019 Dec;38(12):2331-2339
Grupper A, Ehrenwald M, Schwartz D, Berliner S, Shashar M, Baruch R, Schwartz IF, Rogowski O, Zeltser D, Shapira I, Shenhar-Tsarfaty S.J Clin Hypertens (Greenwich). 2019 Aug;21(8):1171-1179
Exercise-induced cardiac troponin in the era of high sensitivity assays: What makes our heart sweat?
Brzezinski RY, Milwidsky A, Shenhar-Tsarfaty S.Int J Cardiol. 2019 Aug 1;288:19-21.
Fisher E, Brzezinski RY, Ehrenwald M, Shapira I, Zeltser D, Berliner S, Marcus Y, Shefer G, Stern N, Rogowski O, Halperin E, Rosset S, Shenhar-Tsarfaty S.Int J Obes (Lond). 2019 Apr;43(4):800-807
Shenhar-Tsarfaty S, Sherf-Dagan S, Berman G, Webb M, Raziel A, Keidar A, Goitein D, Sakran N, Zwang E, Shapira I, Zeltser D, Berliner S, Rogowski O, Shibolet O, Zelber-Sagi S.Int J Obes (Lond). 2019 Feb;43(2):297-305.
